Thomas Scholz, MD
Research Profile
Contact Information:
Office Tel: (319) 356-3539
thomas-scholz@uiowa.edu
Education:
Higher Education
1977-81, BS, Swarthmore College, Swarthmore, Pennsylvania
1981-85, MD, Washington University School of Medicine
Postgraduate Medical Education
1985-88, Pediatric Residency, University of Iowa Hospitals and Clinics, Iowa City, IA
1975-1980, Pediatric Cardiology Fellowship, University of Iowa Hospitals and Clinics, Iowa City, IA
1991-93, Research Associate, National Institute of Health, Laboratory of Cardiac Energetics, Bethesda, MD
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Research Interests:
- Fetal and postnatal development of myocardial energy producing reactions.
- Mechanisms of postnatal cardiac remodeling.
- Studies exploring the impact of the fetal environment on postnatal mitochondrial function and cardiac performance.
- Automated analysis of cardiac magnetic resonance images in patients with congenital heart disease.
Current Projects:
- Development of myocardial reducing equivalent shuttles and their regulatory enzymes.
- Fetal programming of mitochondrial reactive oxygen species production.
- Mechanisms of myocardial remodeling in the offspring of diabetic mothers.
- Automated analysis of magnetic resonance images of the right ventricle in patients with tetralogy of Fallot and of the aorta in patients with connective diseases.
Affiliations: Department of Pediatrics
Recent Publications:
- Hammel JM, Caldarone CA, VanNatta TL, Wang L, Welke KF, Li W, Niles S, Barner E, Scholz TD, Behrendt, DM, Segar JL. Myocardial apoptosis after cardioplegic arrest in the neonatal lamb. J Thorac Cardiovasc Surg 125:1268-1275, 2003.
- Karimi M, Wang L, Hammel JM, Mascio CE, Abdulhamid M, Barner EW, Scholz TD, Segar JL, Li WG, Niles SD, Caldarone CA. Neonatal vulnerability to ischemia and reperfusion: Cardioplegic arrest causes greater myocardial apoptosis in neonatal lambs than in mature lambs. J Thorac Cardiovasc Surg 127:490-497, 2004.
- Roghair RD, Lamb FS, Bedell KA, Smith OM, Scholz TD, Segar JL. Late-gestation betamethasone enhances coronary artery responsiveness to angiotensin II in fetal sheep. Am J Physiol (Regulatory Integrative Comp Physiol) 286: R80-R88, 2004.
- Bartlett HB, Scholz TD, Lamb FS, Weeks DL. Characterization of embryonic cardiac pacemaker and atrioventricular conduction physiology in Xenopus laevis using non-invasive imaging. Am J Physiol (Heart Circ Physiol) 286:H2035-H2041, 2004.
- Caldarone CA, Barner EW, Wang L, Karimi M, Mascio CE, Hammel JM, Segar JL, Scholz TD. Apoptosis-related mitochondrial dysfunction in early postoperative neonatal lamb heart. Ann Thorac Surg 78:948-955, 2004.
- Ralphe JC, Segar JL, Schutte BT, Scholz TD. Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria. J Mol Cell Cardiol 37:33-41, 2004.
- Van Natta TL, Ralphe JC, Mascio CE, Bedell KA, Scholz TD, Segar JL. Ontogeny of vascular growth factors in perinatal sheep myocardium. J Soc Gynecol Investig 11:503-510, 2004.
- Ralphe CE, Bedell KA, Segar JL, Scholz TD. Correlation between myocardial malate/aspartate shuttle activity and EAAT1 protein expression in hyper- and hypothyroidism. Am J Physiol (Heart Circ Physiol) 288:H521-526, 2005.
- Roghair RD, Lamb FS, Miller FJ, Scholz TD, Segar JL. Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity. Am J Physiol (Regul Integr Comp Physiol) 288:R46-R53, 2005.
- Mascio CE, Olson AK, Ralphe JC, Tomanek RJ, Scholz TD, Segar JL. Myocardial vascular and metabolic adaptations in chronically anemic fetal sheep. Am J Physiol (Regul Integr Comp Physiol) 289:R1736-R1745, 2005.
- Bu L, Munns S, Zhang H, Disterhoft M, Dixson M, Stolpen A, Sonka M, Scholz TD, Mahoney LT, Ge S. Rapid full volume data acquisition by real-time 3-dimensional echocardiography for assessment of left ventricular indexes in children: a validation study compared with magnetic resonance imaging. J Am Soc Echocardiogr 18:299-305, 2005.
- Ralphe JC, Nau PN, Segar JL, Scholz TD. Regulation of myocardial glucose transporters in the chronically anemic fetal heart. Pediatr Res 58:713-718, 2005.
- Roghair RD, Segar JL, Sharma RV, Zimmerman MC, Jagadeesha DK, Segar EM, Scholz TD, Lamb FS. Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone prior to onset of systemic hypertension. Am J Physiol (Regul Integr Comp Physiol) 289:R1169-R1176, 2005.
- Olson AK, Protheroe KN, Segar JL, Scholz TD. Mitogen-activated protein kinase activation and regulation in pressure-loaded fetal ovine heart. Am J Physiol (Heart Circ Physiol) 290:H1587-H1595, 2005.
- Olson AK, Protheroe KN Scholz TD, Segar JL. The mitogen-activated protein kinases and Akt are developmentally regulated in the chronically anemic fetal sheep heart. J Soc Gynecol Investig 13:157-165, 2006.
- Segar JL, Roghair RD, Segar, EM, Scholz TD, Lamb FS. Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs prior to hypertension. Am J Physiol (Regul Integr Comp Physiol) 291:R481-R488, 2006.
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