Clinical Trials

What are clinical trials?

The following list represents current trials offered by the Department of Radiation Oncology. A brief description of the clinical trials is offered for referring physicians. If you think you are eligible for a trial, and would like to enroll, please have your doctor contact the Department of Radiation Oncology at (319) 384-9425.

IRB 200502799: Biodistribution and radiation dosimetry of F-18 Flurothymidine (FLT) with Positron Emission Tomography (PET) in patients with head and neck cancer:  a radioactive drug research committee (RDRC) study. PI: Ken Dornfeld, MD, PhD.

This study seeks to determine the biodistribution of FLT, a novel imaging agent for cancers, in patients with head and neck cancer.  Patients being treated with (chemo)radiotherapy with cancers in a certain locations are eligible to participate. For further information, physicians may contact the Radiation Oncology Clinical Trials office at (319) 384-9425.

IRB 200408035: Treatment of adults with newly diagnosed glioblastoma multiforme or anaplastic astrocytoma with surgery, Gliadel Wafers®, and limited field radiation plus concomitant temozolomide followed by adjuvant temozolomide PI: Timothy Ryken, MD; Co-PI: John Buatti, MD

This study seeks to validate a combinatorial therapeutic regimen for glioblastoma multiforme and anaplastic astrocytoma patients. Eligibility criteria include definitive diagnosis of glioblastoma multiforme or anaplastic astrocytoma. For further information, physicians may contact the Radiation Oncology Clinical Trials office at (319) 384-9425.

IRB200211003: Development of radiation fibrosis in patients treated with pentoxifylline and vitamin E: a prospective randomized study . PI: Geraldine Jacobson, MD, MPH;  Co-PI:  Ken Dornfeld, MD, PhD.

This study seeks to determine the efficacy of using pentoxifylline combined with vitamin E in the prevention of radiation fibrosis. Eligibility criteria includes treatment for breast or head and neck cancer with radiation. For further information, physicians may contact the Radiation Oncology Clinical Trials office at (319) 384-9425.

IRB200507777: CT-based planning of high dose rate tandem and ovoid applications
PI: Geraldine Jacobson, MD, MPH

This study seeks to determine the potential value of using CT for dosimetric planning of high-dose rate brachytherapy. Potential subjects should have confirmed carcinoma of the cervix or endometrium and deemed inoperable. For further information, physicians may contact the Radiation Oncology Clinical Trials office at (319) 384-9425.

All clinical trials are governed by the Human Subjects Office at the University of IowaIf you have questions about the rights of research subjects or research related injury, please contact:

The Human Subjects Office
300 College of Medicine Administration Building
The University of Iowa
Iowa City IA 52242
(319) 335-6564
e-mail: irb@uiowa.edu